2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-153337A
    Pomalidomide-C11-NH2 hydrochloride 2722611-55-2
    Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-C11-NH2 hydrochloride
  • HY-163937
    (S,R,S)-AHPC-O-CF3 -CO-cyclohexane
    (S,R,S)-AHPC-O-CF3 -CO-cyclohexane is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-O-CF3 -CO-cyclohexane can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873).
    (S,R,S)-AHPC-O-CF3 -CO-cyclohexane
  • HY-139335
    VH 101 phenol-alkylC4-amine dihydrochloride 2564467-03-2
    VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), and incorporates an E3 ligase ligand plus an alkylC4 linker. VH 101 phenol-alkylC4-amine dihydrochloride can be used for PROTAC research extracted from patent WO2022051326A1.
    VH 101 phenol-alkylC4-amine dihydrochloride
  • HY-W584515
    Thalidomide-NH-(CH2)3-NH-Boc 2093386-36-6
    Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.
    Thalidomide-NH-(CH2)3-NH-Boc
  • HY-159679
    E3 Ligase Ligand-linker Conjugate 116 2409844-90-0
    E3 Ligase Ligand-linker Conjugate 116 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 116 can be used to synthesize PROTAC SMARCA2/4-degrader-28 (HY-162835).
    E3 Ligase Ligand-linker Conjugate 116
  • HY-176366
    AHPC-PEG6-CH2COOH 2361117-11-3
    AHPC-PEG6-CH2COOH is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand and 6-unit PEG linker (HY-122702). AHPC-PEG6-CH2COOH can be used for synthesis of PROTAC CMP98 (HY-136257).
    AHPC-PEG6-CH2COOH
  • HY-138847
    Thalidomide-O-C3-NH2 2509360-22-7
    Thalidomide-O-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-C3-NH2
  • HY-180986
    cis-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl
    Cis-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl is a synthetic E3 ligand-connector conjugate that can be used for the synthesis of Azo-PROTAC-4C-cis (HY-180985).
    cis-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl
  • HY-159683
    E3 Ligase Ligand-linker Conjugate 117
    E3 Ligase Ligand-linker Conjugate 117 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 117 can be used to synthesize PROTAC SMARCA2/4-degrader-29 (HY-162743).
    E3 Ligase Ligand-linker Conjugate 117
  • HY-168235
    (S,R,S)-AHPC-Me-amide-C9-acid 2376139-66-9
    (S,R,S)-AHPC-Me-amide-C9-acid is a E3 ligase ligand-linker conjugate, used for the synthesis of PROTAC SMARCA2 degrader-31 (HY-168234).
    (S,R,S)-AHPC-Me-amide-C9-acid
  • HY-172185
    E3 Ligase Ligand-linker Conjugate 172
    E3 Ligase Ligand-linker Conjugate 172 is the conjugate composed of an E3 ligase ligand and a linker, and can be used for synthesis of PROTAC degrader FF2039 (HY-172159).
    E3 Ligase Ligand-linker Conjugate 172
  • HY-181737
    E3 Ligase Ligand-linker Conjugate 225
    E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732).
    E3 Ligase Ligand-linker Conjugate 225
  • HY-178069
    (S,R,S)-AHPC-CO-PEG3-NHBoc 2493430-80-9
    (S,R,S)-AHPC-CO-PEG3-NHBoc is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC G9a/GLP degrader 1 (HY-178065). PROTAC G9a/GLP degrader 1 is a potent G9a/GLP PROTAC degrader with anti-cancer activity.
    (S,R,S)-AHPC-CO-PEG3-NHBoc
  • HY-155256
    Thalidomide-5-PEG6-NH2 hydrochloride 99.20%
    Thalidomide-5-PEG6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-5-PEG6-NH2 hydrochloride
  • HY-178197
    E3 Ligase Ligand-linker Conjugate 210
    E3 Ligase Ligand-linker Conjugate 210 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 210 can be used to synthesize PROTAC CB1R Degrader-1 (HY-178176).
    E3 Ligase Ligand-linker Conjugate 210
  • HY-174220
    Boc-Dipiperidine-KLHDC2 ligand 1
    Boc-Dipiperidine-KLHDC2 ligand 1 is an E3 ligase ligand-linker conjugate that incorporates a KLHDC2 ligand (HY-174218). Boc-Dipiperidine-KLHDC2 ligand 1 can be used for synthesis of PROTAC BRD4 Degrader-31 (HY-174210).
    Boc-Dipiperidine-KLHDC2 ligand 1
  • HY-180906
    (S,R,S)-AHPC-C2-PEG3-NH2 2243090-28-8
    (S,R,S)-AHPC-C2-PEG3-NH2 is an E3 ligase ligand-linker conjugate, can be used for synthesis of PROTAC USP39 Degrader-1 (HY-180907).
    (S,R,S)-AHPC-C2-PEG3-NH2
  • HY-145715
    Azido-PEG2-VHL 2597167-22-9
    Azido-PEG2-VHL is a multikinase degrader which can be used in the synthesis of PROTACs. Azido-PEG2-VHL is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-VHL
  • HY-157747
    E3 Ligase Ligand-linker Conjugate 99
    E3 Ligase Ligand-linker Conjugate 99 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 Ligase Ligand-linker Conjugate 99
  • HY-157515
    Thalidomide 4'-ether-PEG2-azide 2758431-90-0
    Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs.
    Thalidomide 4'-ether-PEG2-azide
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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